Properties of the transient outward, ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation
نویسندگان
چکیده
Background Atrial fibrillation (AF) is a common and severe arrhythmia, which largely affects quality of life. State-of-the-art treatment of AF still relies heavily on pharmacological modalities. Therefore, the aim of the present study was to investigate and compare the properties of three repolarizing currents which contribute to AF-induced remodeling, i.e. the transient outward (Ito), ultra-rapid delayed rectifier (IKur) and acetylcholine-sensitive potassium currents (IK, ACh) in isolated atrial myocytes obtained from normal (SR) and tachypaced model of permanent atrial fibrillation (ATR) dogs.
منابع مشابه
Title Pharmacology of Cardiac Potassium Channels
Cardiac K channels are cardiomyocyte membrane proteins that regulate K ion flow across the cell membrane on the electrochemical gradient, and determine the resting membrane potential and the cardiac action potential morphology and duration. Several K channels have been well studied in the human heart. They include the transient outward K current Ito1, the ultra-rapidly delayed rectifier current...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011